From: owner-ammf-digest@smoe.org (alt.music.moxy-fruvous digest) To: ammf-digest@smoe.org Subject: alt.music.moxy-fruvous digest V14 #5087 Reply-To: ammf@fruvous.com Sender: owner-ammf-digest@smoe.org Errors-To: owner-ammf-digest@smoe.org Precedence: bulk alt.music.moxy-fruvous digest Wednesday, October 7 2020 Volume 14 : Number 5087 Today's Subjects: ----------------- Any man out there add length and girth in under one minute... ["Massive M] ---------------------------------------------------------------------- Date: Wed, 7 Oct 2020 10:13:57 -0400 From: "Massive Male Plus Basic" Subject: Any man out there add length and girth in under one minute... Any man out there add length and girth in under one minute... http://dronesys.today/-c-McA5gTSlgyxbRNZy-3q4dascFDSIQpucQqhf16I_siIUq http://dronesys.today/IXga-0EsssVAs7uzxTcYkcPSYy9r2VY3w6OP5FRcY6odcdJo Different types of proteases help cleave the proteins in different formats. There are serine, aspartate, metalloproteases, and many other classes. All use different mechanisms to cleave the peptide bonds to begin protein degradation. For example, the serine proteases, such as trypsin, engage in a nucleophilic attack on the hydroxyl oxygen of the serine on the peptide bond's carbonyl carbon in order to cleave this bond. An acyl-enzyme intermediate is created and the mechanism continues to hydrolize the other remaining linkages. On the other hand, metalloproteases, such as zinc proteases, incorporate metals to break the bonds. With zinc, its active site incorporates the zinc ion, water, and histidines (which are ligands to the zinc ion). The zinc protease also engages in a nucleophilic attack but on the carbonyl carbon, using the water's oxygen atom. The active site's base helps this process along by taking a proton from that water. In certain organisms, such as bacteria, the proteins must undergo proteolysis before the amino acids can be re-polymerized into new proteins because the original proteins cannot pass through the bacterial plasma membrane, as they are too large. After the proteins are broken down into amino acids through proteolysis, these amino acids will be able to pass through the membranes of bacteria and will once again congregate to form new proteins that the bacteria needs to function. Amino Acids feeding into TCA Cycle Amino acid degradation Oxidative deamination is the first step to breaking down the amino acids so that they can be converted to sugars. The process begins by removing the amino group of the amino acids. The amino group becomes ammonium as it is lost and later undergoes the urea cycle to become urea, in the liver. It is then released into the blood stream, where it is transferred to the kidneys, which will secrete the urea as urine. The remaining portion of the amino acid becomes oxidized, resulting in an alpha-keto acid. The alpha-keto acid will then proceed into the TCA cycle, in order to produce energy. The acid can also enter glycolysis, where it will be eventually converted into pyruvate. The pyruvate is then converted into acetyl-CoA so that it can enter the TCA cycle and convert the original pyruvate molecules into ATP, or usable energy for the organism. Transamination leads to the same end result as deamination: the remaining acid will undergo either glycolysis or the TCA cycle to produce energy that the organism's body will use for various purposes. This process transfers the amino group ------------------------------ End of alt.music.moxy-fruvous digest V14 #5087 **********************************************