From: owner-ammf-digest@smoe.org (alt.music.moxy-fruvous digest) To: ammf-digest@smoe.org Subject: alt.music.moxy-fruvous digest V14 #5024 Reply-To: ammf@fruvous.com Sender: owner-ammf-digest@smoe.org Errors-To: owner-ammf-digest@smoe.org Precedence: bulk alt.music.moxy-fruvous digest Sunday, September 27 2020 Volume 14 : Number 5024 Today's Subjects: ----------------- This might be the Single Best Opportunity You have been Looking For! ["Cr] The Best Natural Painkiller that Grows in Your Backyard ["Natural Painkil] ---------------------------------------------------------------------- Date: Sat, 26 Sep 2020 07:28:38 -0400 From: "Crypto Insiders" Subject: This might be the Single Best Opportunity You have been Looking For! This might be the Single Best Opportunity You have been Looking For! http://solidgoldcredit.buzz/cwwTOAAC289FYK-C-UxOw4Ca0XTIN_Hu7YII4b8OE09Vr6Xt http://solidgoldcredit.buzz/nTfALCfWAc0XwCGnu6dBY18wp4vtHiZUUPY_ILnU5Rs8EOw uli utilized and the cell type. HIV progression The progression of the human immunodeficiency virus infection into AIDS is due primarily to the depletion of CD4+ T-helper lymphocytes in a manner that is too rapid for the body's bone marrow to replenish the cells, leading to a compromised immune system. One of the mechanisms by which T-helper cells are depleted is apoptosis, which results from a series of biochemical pathways: HIV enzymes deactivate anti-apoptotic Bcl-2. This does not directly cause cell death but primes the cell for apoptosis should the appropriate signal be received. In parallel, these enzymes activate proapoptotic procaspase-8, which does directly activate the mitochondrial events of apoptosis. HIV may increase the level of cellular proteins that prompt Fas-mediated apoptosis. HIV proteins decrease the amount of CD4 glycoprotein marker present on the cell membrane. Released viral particles and proteins present in extracellular fluid are able to induce apoptosis in nearby "bystander" T helper cells. HIV decreases the production of molecules involved in marking the cell for apoptosis, giving the virus time to replicate and continue releasing apoptotic agents and virions into the surrounding tissue. The infected CD4+ cell may also receive the death signal from a cytotoxic T cell. Cells may also die as direct consequences of viral infections. HIV-1 expression induces tubular cell G2/M arrest and apoptosis. The progression from HIV to AIDS is not immediate or even necessarily rapid; HIV's cytotoxic activity toward CD4+ lymphocytes is classified as AIDS once a given patient's CD4+ cell count falls below 200. Researchers from Kumamoto University in Japan have developed a new method to eradicate HIV in viral reservoir cells, named "Lock-in and apoptosis." Using the synthesized compound Heptanoylphosphatidyl L-Inositol Pentakisphophate (or L-Hippo) to bind strongly to the HIV protein PR55Gag, they were able to suppress viral budding. By suppressing viral budding, the researchers were able to trap the HIV virus in the cell and allow for the cell to undergo apoptosis (natural cell death). Associate Professor Mikako Fujita has stated that the approach is not yet available to HIV patients because the research team has to conduct further research on combining the drug therapy that currently exists with this "Lock-in and apoptosis" approach to lead to complete recover ------------------------------ Date: Sat, 26 Sep 2020 10:07:07 -0400 From: "Natural Painkiller" Subject: The Best Natural Painkiller that Grows in Your Backyard The Best Natural Painkiller that Grows in Your Backyard http://penisremedy.buzz/FaYKhTnuDyI2SCvlmczo4nCM033BL62SDYvtFSZv1A02iHND http://penisremedy.buzz/-eRLeqE6PQmzQF7qxq2vAg2ECLuxcAYDbQ_M3Qep9eBhMe01 imbs, dragging their hindquarters in a similar manner to that used by the elephant seal. In the early Carboniferous (360 to 345 million years ago), the climate became wet and warm. Extensive swamps developed with mosses, ferns, horsetails and calamites. Air-breathing arthropods evolved and invaded the land where they provided food for the carnivorous amphibians that began to adapt to the terrestrial environment. There were no other tetrapods on the land and the amphibians were at the top of the food chain, occupying the ecological position currently held by the crocodile. Though equipped with limbs and the ability to breathe air, most still had a long tapering body and strong tail. They were the top land predators, sometimes reaching several metres in length, preying on the large insects of the period and the many types of fish in the water. They still needed to return to water to lay their shell-less eggs, and even most modern amphibians have a fully aquatic larval stage with gills like their fish ancestors. It was the development of the amniotic egg, which prevents the developing embryo from drying out, that enabled the reptiles to reproduce on land and which led to their dominance in the period that followed. After the Carboniferous rainforest collapse amphibian dominance gave way to reptiles, and amphibians were further devastated by the PermianbTriassic extinction event. During the Triassic Period (250 to 200 million years ago), the reptiles continued to out-compete the amphibians, leading to a reduction in both the amphibians' size and their importance in the biosphere. According to the fossil record, Lissamphibia, which includes all modern amphibians and is the only surviving lineage, may have branched off from the extinct groups Temnospondyli and Lepospondyli at some period between the Late Carboniferous and the Early Triassic. The relative scarcity of fossil evidence precludes precise dating, but the most recent molecular study, based on multilocus sequence typing, suggests a Late Carboniferous/Early Permian origin for extant amphibians. Eryops The temnospondyl Eryops had sturdy limbs to support its body on land The origins and evolutionary relationships between the three main groups of amphibians is a matter of debate. A 2005 molecular phylogeny, based on rDNA analysis, suggests that salamanders and caecilians are more closely related to each other than they are to frogs. It also appears that the divergence of the three groups took place in the Paleozoic or early Mesozoic (around 250 million years ago), before the breakup of the supercontinent Pangaea and soon after their divergence from the lobe-finned fish. The briefness of this period, and the swiftness with which radiation took place, would help account for the rela ------------------------------ End of alt.music.moxy-fruvous digest V14 #5024 **********************************************