From: owner-ammf-digest@smoe.org (alt.music.moxy-fruvous digest) To: ammf-digest@smoe.org Subject: alt.music.moxy-fruvous digest V14 #4707 Reply-To: ammf@fruvous.com Sender: owner-ammf-digest@smoe.org Errors-To: owner-ammf-digest@smoe.org Precedence: bulk alt.music.moxy-fruvous digest Thursday, August 6 2020 Volume 14 : Number 4707 Today's Subjects: ----------------- It actually attracts them, then catches and kills them! ["Flying Pests" <] Why that Blaze in Your Belly Stoked by Bread is so Dangerous... ["Keto Br] The secret starts with a NEW protein enzyme that targets abdominal fat (according to doctors) ["Burn Stubborn Fat" Subject: It actually attracts them, then catches and kills them! It actually attracts them, then catches and kills them! http://byeinsect.buzz/WCVCUcsbLoI2ykPK2rcHmyFDw0y5x_oL2Jsap0JYnQUoMQ http://byeinsect.buzz/HPfEUIkDBSaz4qgUcp5tM_auHvo2SVBZenJZQV-3B5c45w Questions in computational neuroscience can span a wide range of levels of traditional analysis, such as development, structure, and cognitive functions of the brain. Research in this field utilizes mathematical models, theoretical analysis, and computer simulation to describe and verify biologically plausible neurons and nervous systems. For example, biological neuron models are mathematical descriptions of spiking neurons which can be used to describe both the behavior of single neurons as well as the dynamics of neural networks. Computational neuroscience is often referred to as theoretical neuroscience. Nanoparticles in medicine are versatile in treating neurological disorders showing promising results in mediating drug transport across the blood brain barrier. Implementing nanoparticles in antiepileptic drugs enhances their medical efficacy by increasing bioavailability in the bloodstream, as well as offering a measure of control in release time concentration. Although nanoparticles can assist therapeutic drugs by adjusting physical properties to achieve desirable effects, inadvertent increases in toxicity often occur in preliminary drug trials. Furthermore, production of nanomedicine for drug trials is economically consuming, hindering progress in their implementation. Computational models in nanoneuroscience provide alternatives to study the efficacy of nanotechnology based medicines in neurological disorders while mitigating potential side effects and development costs. Nanomaterials often operate at length scales between classical and quantum regimes. Due to the associated uncertainties at the length scales that nanomaterials operate, it is difficult to predict their behavior prior to in vivo studies. Classically, the physical processes which occur throughout neurons are analogous to electrical circuits. Designers focus on such analogies and model brain activity as a neural circuit. Success in computational modeling of neurons have led to the development of stereochemical models that accurately predict acetylcholine receptor-based synapses operating at microsecond time scales. Ultrafine nanoneedles for cellular manipulations are thinner than the smallest single walled carbon nanotubes. Computational quantum chemistry is used to design ultrafine nanomaterials with highly-symmetrical structures to optimize geometry, reactivity and stability. Behavior of nanomaterials are dominated by long ranged non-bonding interactions. Electrochemical processes that occur throughout the brain generate an electric field which can inadvertently affect the behavior of some nanomaterials. Molecular dynamics simulations can mitigate the development phase of nanomaterials as well as prevent neural toxicity of nanomaterials following in vivo clinical trials. Testing nanomaterials using molecular dynamics optimizes nano characteristics for therapeutic purposes by testing different environment conditions, nanomaterial shape fabrications, nanomaterial surface properties, etc without the need for in vivo experimentation. Flexibility in molecular dynamic simulations allows medical practitioners to personalize treatment. Nanoparticle related data from translational nanoinformatics links neurological patient specific data to predict treatment response ------------------------------ Date: Wed, 5 Aug 2020 08:43:53 -0400 From: "Keto Bread" <**KetoBread**@breaddessert.buzz> Subject: Why that Blaze in Your Belly Stoked by Bread is so Dangerous... Why that Blaze in Your Belly Stoked by Bread is so Dangerous... http://breaddessert.buzz/Xp-2kPcdONVvf_phxWo5gaU2gqLH88OuFdUPLPeI8ZlTuPEh http://breaddessert.buzz/l0Ap-EQrBjWM5mxqO7qCzUKTh7H-qkU8sfWtORkKKG31M0Nl Comparative morphology is analysis of the patterns of the locus of structures within the body plan of an organism, and forms the basis of taxonomical categorization. Functional morphology is the study of the relationship between the structure and function of morphological features. Experimental morphology is the study of the effects of external factors upon the morphology of organisms under experimental conditions, such as the effect of genetic mutation. Anatomy is a "branch of morphology that deals with the structure of organisms". Molecular morphology is a rarely used term, usually referring to the superstructure of polymers such as fiber formation or to larger composite assemblies. The term is commonly not applied to the spatial structure of individual molecules. Gross morphology refers to the collective structures of an organism as a whole as a general description of the form and structure of an organism, taking into account all of its structures without specifying an individual structure. Morphology and classification Most taxa differ morphologically from other taxa. Typically, closely related taxa differ much less than more distantly related ones, but there are exceptions to this. Cryptic species are species which look very similar, or perhaps even outwardly identical, but are reproductively isolated. Conversely, sometimes unrelated taxa acquire a similar appearance as a result of convergent evolution or even mimicry. In addition, there can be morphological differences within a species, such as in Apoica flavissima where queens are significantly smaller than workers. A further problem with relying on morphological data is that what may appear, morphologically speaking, to be two distinct species, may in fact be shown by DNA analysis to be a single species. The significance of these differences can be examined through the use of allometric engineering in which one or both species are manipulated to phenocopy the other species. A step relevant to the evaluation of morphology between traits/features within species, includes an assessment of the terms: homology and homoplasy. Homology between features indicate that those features have been derived from a common ancestor. Alternatively, homoplasy between features describes those that can resemble each other, but derive independently via parallel or convergent ------------------------------ Date: Wed, 5 Aug 2020 10:41:18 -0400 From: "Burn Stubborn Fat" Subject: The secret starts with a NEW protein enzyme that targets abdominal fat (according to doctors) The secret starts with a NEW protein enzyme that targets abdominal fat (according to doctors) http://carbfix.buzz/VLFgNmujGrZdYUTzitEzCVIMzJEODMgnWkvGGA4AUhSWE61E http://carbfix.buzz/EaSm3YVP1y-Jm9DZbygYq9vNt8Rx4tHSFi_oIjSp6_vP_jE Another proposed way to cross the BBB is through temporary intentional disruption of the barrier. This method was first inspired by certain pathological conditions that were discovered to break down this barrier by themselves, such as Alzheimerbs disease, Parkinsonbs disease, stroke, and seizure conditions. Nanoparticles are unique from macromolecules because their surface properties are dependent on their size, allowing for strategic manipulation of these properties (or, bprogrammingb) by scientists that would not be possible otherwise. Likewise, nanoparticle shape can also be varied to give a different set of characteristics based on the surface area to volume ratio of the particle. Nanoparticles have promising therapeutic effects when treating neurodegenerative diseases. Oxygen reactive polymer (ORP) is a nano-platform programmed to react with oxygen and has been shown to detect and reduce the presence of reactive oxygen species (ROS) formed immediately after traumatic brain injuries. Nanoparticles have also been employed as a bneuroprotectiveb measure, as is the case with Alzheimerbs disease and stroke models. Alzheimerbs disease results in toxic aggregates of the amyloid beta protein formed in the brain. In one study, gold nanoparticles were programmed to attach themselves to these aggregates and were successful in breaking them up. Likewise, with ischemic stroke models, cells in the affected region of the brain undergo apoptosis, dramatically reducing blood flow to important parts of the brain and often resulting in death or severe mental and physical changes. Platinum nanoparticles have been shown to act as ROS, serving as bbiological antioxidantsb and significantly reducing oxidation in the brain as a result of stroke. Nanoparticles can also lead to neurotoxicity and cause permanent BBB damage either from brain oedema or from unrelated molecules crossing the BBB and causing brain damage. This proves further long term in vivo studies are needed to gain enough understanding to allow for successful clinical trials. One of the most common nano-based drug delivery platforms is liposome-based delivery. They are both lipid-soluble and nano-scale and thus are permitted through a fully-functioning BBB. Additionally, lipids themselves are biological molecules, making them highly biocompatible, which in turn lowers the risk of cell toxicity. The bilayer that is formed allows the molecule to fully encapsulate any drug, protecting it while it is travelling through the body. One drawback to shielding the drug from the outside cells is that it no longer has specificity, and requires coupling to extra antibodies to be able to target a biological site. Due to their low stability, liposome based nanoparticles for drug delivery have a short shelf life. Targeted therapy using magnetic nanoparticles (MNPs) is also a popular topic of research and has led to several stage III clinical trials. Invasiveness is not an issue here because a magnetic force can be applied from the outside of a patientbs body to interact and direct the MNPs. This strategy has been proven successful in delivering Brain-derived neurotropic factor, a naturally occurring gene thought to promote neurorehabilitation, across the BBB ------------------------------ End of alt.music.moxy-fruvous digest V14 #4707 **********************************************