From: owner-ammf-digest@smoe.org (alt.music.moxy-fruvous digest) To: ammf-digest@smoe.org Subject: alt.music.moxy-fruvous digest V14 #13075 Reply-To: ammf@fruvous.com Sender: owner-ammf-digest@smoe.org Errors-To: owner-ammf-digest@smoe.org Precedence: bulk alt.music.moxy-fruvous digest Monday, January 22 2024 Volume 14 : Number 13075 Today's Subjects: ----------------- Oriental Blue Tonic Melts 63 pounds of fat ["Stubborn Fat" Subject: Oriental Blue Tonic Melts 63 pounds of fat Oriental Blue Tonic Melts 63 pounds of fat http://reliver.best/OCInAgv10qItTWpH1nMTyoCFrMAPaUyUC_5nXLNQx7OBW0uqJA http://reliver.best/OJbRWnmT1QDRgZr5BwitsSKswrNi6fAySxQeisIpC-bWDWNilQ TNF-alpha is a cytokine produced mainly by activated macrophages, and is the major extrinsic mediator of apoptosis. Most cells in the human body have two receptors for TNF-alpha: TNFR1 and TNFR2. The binding of TNF-alpha to TNFR1 has been shown to initiate the pathway that leads to caspase activation via the intermediate membrane proteins TNF receptor-associated death domain (TRADD) and Fas-associated death domain protein (FADD). cIAP1/2 can inhibit TNF-? signaling by binding to TRAF2. FLIP inhibits the activation of caspase-8. Binding of this receptor can also indirectly lead to the activation of transcription factors involved in cell survival and inflammatory responses. However, signalling through TNFR1 might also induce apoptosis in a caspase-independent manner. The link between TNF-alpha and apoptosis shows why an abnormal production of TNF-alpha plays a fundamental role in several human diseases, especially in autoimmune diseases. The TNF-alpha receptor superfamily also includes death receptors (DRs), such as DR4 and DR5. These ------------------------------ End of alt.music.moxy-fruvous digest V14 #13075 ***********************************************