From: owner-ammf-digest@smoe.org (alt.music.moxy-fruvous digest) To: ammf-digest@smoe.org Subject: alt.music.moxy-fruvous digest V14 #11609 Reply-To: ammf@fruvous.com Sender: owner-ammf-digest@smoe.org Errors-To: owner-ammf-digest@smoe.org Precedence: bulk alt.music.moxy-fruvous digest Tuesday, June 13 2023 Volume 14 : Number 11609 Today's Subjects: ----------------- Pre-meal tip saved 9,065 men from balding ["Hair Loss Solution" Subject: Pre-meal tip saved 9,065 men from balding Pre-meal tip saved 9,065 men from balding http://samsurveymachine.shop/IRl1t1ROvcQ_FDTj1e-malcwhjP_ggPEkMp_kPz2fIbwmLn_Zw http://samsurveymachine.shop/0Lz-6cV-AdWAcC_dDCwMK8kLoWCBaC6hvwSBfKOU_rz9e8WmqQ The genomes of viruses and prokaryotes encode a relatively well-defined proteome as each protein can be predicted with high confidence, based on its open reading frame (in viruses ranging from ~3 to ~1000, in bacteria ranging from about 500 proteins to about 10,000). However, most protein prediction algorithms use certain cut-offs, such as 50 or 100 amino acids, so small proteins are often missed by such predictions. In eukaryotes this becomes much more complicated as more than one protein can be produced from most genes due to alternative splicing (e.g. human proteome encodes about 20,000 proteins, but some estimates predicted 92,179 proteins[citation needed] out of which 71,173 are splicing variants[citation needed]). Proteoforms. There are different factors that can add variability to proteins. SAPs (single amino acid polymorphisms) and non-synonymous single nucleotide polymorphisms (nsSNPs) can lead to different "proteoforms" or "proteomorphs". Recent estimates have found ~135,000 validated nonsynonymous cSNPs currently housed within SwissProt. In dbSNP, there are 4.7 million candidate cSNPs, yet only ~670,000 cSNPs have been validated in the 1,000-genomes set as nonsynonymous cSNPs that change the identity of an amino acid in a protein. Dark proteome. The term dark proteome coined by PerdigC#o and colleagues, defines regions of proteins that have no detectable sequence homology to other proteins of known three-dimensional structure and therefore cannot be modeled by homology. For 546,000 Swiss-Prot proteins, 44b54% of the proteome in eukaryotes and viruses was found to be "dark", compared with only ?14% in archaea and bacteria. Human proteome. Currently, several projects aim to map the human proteome, including the Human Proteome Map, ProteomicsDB, isoform.io, and The Human Proteome Project (HPP). Much like the human genome project, these projects seek to find and collect evidence for all predicted protein coding genes in the human genome. The Human Proteome Map currently (October 2020) claims 17,294 proteins and ProteomicsDB 15,479, using different criteria. On October 16, 2020, the HPP publish ------------------------------ End of alt.music.moxy-fruvous digest V14 #11609 ***********************************************